Abstract
High throughput screening of our compound collection led to the discovery of a novel series of N-alkyl-5H-pyrido[4,3-b]indol-1-amines as urotensin-II receptor antagonists. Synthesis, initial structure and activity relationships, functional and animal ortholog activities of the series are described.
MeSH terms
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Amines / chemical synthesis*
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Amines / chemistry
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Amines / pharmacology*
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Animals
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Combinatorial Chemistry Techniques
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Mice
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Molecular Structure
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Pyridines / pharmacology*
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Structure-Activity Relationship
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Urotensins / antagonists & inhibitors*
Substances
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Amines
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Pyridines
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Urotensins
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urotensin II